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Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies.
Lowe, Kelly; Dawson, Jeffrey; Phillips, Katherine; Minucci, Jeffrey; Wambaugh, John F; Qian, Hua; Ramanarayanan, Tharacad; Egeghy, Peter; Ingle, Brandall; Brunner, Rachel; Mendez, Elizabeth; Embry, Michelle; Tan, Yu-Mei.
Afiliação
  • Lowe K; U.S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
  • Dawson J; U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Washington, DC, USA.
  • Phillips K; U.S. Environmental Protection Agency, Office of Research & Development, Durham, NC, USA.
  • Minucci J; U.S. Environmental Protection Agency, Office of Research & Development, Durham, NC, USA.
  • Wambaugh JF; U.S. Environmental Protection Agency, Office of Research & Development, Durham, NC, USA.
  • Qian H; ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, USA.
  • Ramanarayanan T; Syngenta Ltd., Greensboro, NC, USA.
  • Egeghy P; U.S. Environmental Protection Agency, Office of Research & Development, Durham, NC, USA.
  • Ingle B; U.S. Environmental Protection Agency, Office of Pesticide Program, Durham, NC, USA.
  • Brunner R; U.S. Environmental Protection Agency, Office of Pesticide Program, Durham, NC, USA.
  • Mendez E; U.S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
  • Embry M; Health and Environmental Sciences Institute, Washington, DC, USA. Electronic address: membry@hesiglobal.org.
  • Tan YM; U.S. Environmental Protection Agency, Office of Pesticide Program, Durham, NC, USA.
Regul Toxicol Pharmacol ; 127: 105073, 2021 Dec.
Article em En | MEDLINE | ID: mdl-34743952

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nível de Efeito Adverso não Observado / Experimentação Animal / Relação Dose-Resposta a Droga / Exposição Ambiental / Toxicocinética Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nível de Efeito Adverso não Observado / Experimentação Animal / Relação Dose-Resposta a Droga / Exposição Ambiental / Toxicocinética Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article