Your browser doesn't support javascript.
loading
Dictyostelium Dynamin Superfamily GTPases Implicated in Vesicle Trafficking and Host-Pathogen Interactions.
Katic, Ana; Hüsler, Dario; Letourneur, François; Hilbi, Hubert.
Afiliação
  • Katic A; Institute of Medical Microbiology, University of Zürich, Zurich, Switzerland.
  • Hüsler D; Institute of Medical Microbiology, University of Zürich, Zurich, Switzerland.
  • Letourneur F; Laboratory of Pathogen Host Interactions, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Hilbi H; Institute of Medical Microbiology, University of Zürich, Zurich, Switzerland.
Front Cell Dev Biol ; 9: 731964, 2021.
Article em En | MEDLINE | ID: mdl-34746129
ABSTRACT
The haploid social amoeba Dictyostelium discoideum is a powerful model organism to study vesicle trafficking, motility and migration, cell division, developmental processes, and host cell-pathogen interactions. Dynamin superfamily proteins (DSPs) are large GTPases, which promote membrane fission and fusion, as well as membrane-independent cellular processes. Accordingly, DSPs play crucial roles for vesicle biogenesis and transport, organelle homeostasis, cytokinesis and cell-autonomous immunity. Major progress has been made over the last years in elucidating the function and structure of mammalian DSPs. D. discoideum produces at least eight DSPs, which are involved in membrane dynamics and other processes. The function and structure of these large GTPases has not been fully explored, despite the elaborate genetic and cell biological tools available for D. discoideum. In this review, we focus on the current knowledge about mammalian and D. discoideum DSPs, and we advocate the use of the genetically tractable amoeba to further study the role of DSPs in cell and infection biology. Particular emphasis is put on the virulence mechanisms of the facultative intracellular bacterium Legionella pneumophila.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article