Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An accelerated workflow for evaluation of lead monoclonal antibodies.

Zhu, Shaolong; Liuni, Peter; Chen, Tricia; Houy, Camille; Wilson, Derek J; James, D Andrew

Zhu, Shaolong; Liuni, Peter; Chen, Tricia; Houy, Camille; Wilson, Derek J; James, D Andrew.

Afiliação

Zhu S; Analytical Sciences, Sanofi Pasteur Ltd, Toronto, Ontario, Canada.
Liuni P; Centre for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario, Canada.
Chen T; Analytical Sciences, Sanofi Pasteur Ltd, Toronto, Ontario, Canada.
Houy C; Analytical Sciences, Sanofi Pasteur Ltd, Toronto, Ontario, Canada.
Wilson DJ; Centre for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario, Canada.
James DA; Analytical Sciences, Sanofi Pasteur Ltd, Toronto, Ontario, Canada.

Biotechnol J ; 17(2): e2100358, 2022 Feb.

Article em En | MEDLINE | ID: mdl-34747565

Assuntos

Anticorpos Monoclonais; Espectrometria de Massa com Troca Hidrogênio-Deutério; Deutério; Mapeamento de Epitopos; Epitopos; Fluxo de Trabalho

Palavras-chave

Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS); epitope screening; monoclonal antibody; pertactin; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massa com Troca Hidrogênio-Deutério / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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