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Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski, Charlotte F; Hijaz, Baraa A; Singh, Vijay; Gcwensa, Nolwazi Z; Kelly, Kaela; Boyden, Edward S; West, Andrew B; Sarkar, Deblina; Volpicelli-Daley, Laura A.
Afiliação
  • Brzozowski CF; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Hijaz BA; Interfaculty Institute for Biochemistry, University of Tübingen, 72076, Tübingen, Germany.
  • Singh V; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Gcwensa NZ; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Kelly K; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Boyden ES; Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.
  • West AB; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Sarkar D; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Volpicelli-Daley LA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Acta Neuropathol Commun ; 9(1): 180, 2021 11 08.
Article em En | MEDLINE | ID: mdl-34749824
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transporte Axonal / Receptores Pré-Sinápticos / Alfa-Sinucleína / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transporte Axonal / Receptores Pré-Sinápticos / Alfa-Sinucleína / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article