Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.

Lenoir, W Frank; Morgado, Micaela; DeWeirdt, Peter C; McLaughlin, Megan; Griffith, Audrey L; Sangree, Annabel K; Feeley, Marissa N; Esmaeili Anvar, Nazanin; Kim, Eiru; Bertolet, Lori L; Colic, Medina; Dede, Merve; Doench, John G; Hart, Traver

Lenoir, W Frank; Morgado, Micaela; DeWeirdt, Peter C; McLaughlin, Megan; Griffith, Audrey L; Sangree, Annabel K; Feeley, Marissa N; Esmaeili Anvar, Nazanin; Kim, Eiru; Bertolet, Lori L; Colic, Medina; Dede, Merve; Doench, John G; Hart, Traver.

Afiliação

Lenoir WF; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Morgado M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
DeWeirdt PC; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
McLaughlin M; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Griffith AL; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sangree AK; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Feeley MN; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Esmaeili Anvar N; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kim E; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bertolet LL; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Colic M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dede M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Doench JG; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hart T; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nat Commun ; 12(1): 6506, 2021 11 11.

Article em En | MEDLINE | ID: mdl-34764293

Assuntos

Leucemia Mieloide Aguda/metabolismo; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Proteínas Associadas a CRISPR/genética; Proteínas Associadas a CRISPR/metabolismo; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/fisiologia; Inibidor de Quinase Dependente de Ciclina p21/genética; Endodesoxirribonucleases/genética; Endodesoxirribonucleases/metabolismo; Humanos; Leucemia Mieloide Aguda/genética; Metabolismo dos Lipídeos/genética; Metabolismo dos Lipídeos/fisiologia; Proteína Supressora de Tumor p53/genética; Proteína 1 de Ligação à Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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