Establishment of a Rapid Detection System for ISG20-Dependent SARS-CoV-2 Subreplicon RNA Degradation Induced by Interferon-&#945;.

Furutani, Yutaka; Toguchi, Mariko; Higuchi, Shoko; Yanaka, Kaori; Gailhouste, Luc; Qin, Xian-Yang; Masaki, Takahiro; Ochi, Sae; Matsuura, Tomokazu

Establishment of a Rapid Detection System for ISG20-Dependent SARS-CoV-2 Subreplicon RNA Degradation Induced by Interferon-α.

Furutani, Yutaka; Toguchi, Mariko; Higuchi, Shoko; Yanaka, Kaori; Gailhouste, Luc; Qin, Xian-Yang; Masaki, Takahiro; Ochi, Sae; Matsuura, Tomokazu.

Afiliação

Furutani Y; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Toguchi M; Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Higuchi S; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Yanaka K; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Gailhouste L; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Qin XY; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Masaki T; RIKEN Cluster for Pioneering Research Liver Cancer Prevention Research Unit, Saitama 351-0198, Japan.
Ochi S; Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Matsuura T; Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

Int J Mol Sci ; 22(21)2021 Oct 28.

Article em En | MEDLINE | ID: mdl-34769072

Assuntos

Antivirais/farmacologia; Avaliação Pré-Clínica de Medicamentos/métodos; Interferon-alfa/farmacologia; RNA Viral/metabolismo; SARS-CoV-2/genética; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Exorribonucleases/genética; Vetores Genéticos; Células HeLa; Humanos; Interferon-alfa/administração & dosagem; Luciferases/genética; Luciferases/metabolismo; Naftiridinas/administração & dosagem; Naftiridinas/farmacologia; Oxidiazóis/administração & dosagem; Oxidiazóis/farmacologia; RNA Viral/efeitos dos fármacos; Replicon

Palavras-chave

CDM-3008; COVID-19; ISG20; interferon; interferon-stimulated genes; replicon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / RNA Viral / Interferon-alfa / Avaliação Pré-Clínica de Medicamentos / SARS-CoV-2 Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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