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Horizontal gene transfer and adaptive evolution in bacteria.
Arnold, Brian J; Huang, I-Ting; Hanage, William P.
Afiliação
  • Arnold BJ; Department of Computer Science, Princeton University, Princeton, NJ, USA. brianjohnarnold@gmail.com.
  • Huang IT; Center for Statistics and Machine Learning, Princeton University, Princeton, NJ, USA. brianjohnarnold@gmail.com.
  • Hanage WP; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Nat Rev Microbiol ; 20(4): 206-218, 2022 04.
Article em En | MEDLINE | ID: mdl-34773098
Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can considerably alter bacterial genomes, not all transfer events may be biologically significant and may instead represent the outcome of an incessant evolutionary process that only occasionally has a beneficial purpose. When adaptive transfers occur, HGT and positive selection may result in specific, detectable signatures in genomes, such as gene-specific sweeps or increased transfer rates for genes that are ecologically relevant. In this Review, we first discuss the various mechanisms whereby HGT occurs, how the genetic signatures shape patterns of genomic variation and the distinct bioinformatic algorithms developed to detect these patterns. We then discuss the evolutionary theory behind HGT and positive selection in bacteria, and discuss the approaches developed over the past decade to detect transferred DNA that may be involved in adaptation to new environments.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Transferência Genética Horizontal Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Transferência Genética Horizontal Idioma: En Ano de publicação: 2022 Tipo de documento: Article