Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-<i>&#954;</i>B Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals.

Ma, Xiaoqin; Hao, Chenxia; Zhang, Zhaokang; Jiang, Huiting; Zhang, Weixia; Huang, Jingjing; Chen, Xiaofei; Yang, Wanhua

Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals.

Ma, Xiaoqin; Hao, Chenxia; Zhang, Zhaokang; Jiang, Huiting; Zhang, Weixia; Huang, Jingjing; Chen, Xiaofei; Yang, Wanhua.

Afiliação

Ma X; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao C; Department of Pharmacy, Xi'an Children's Hospital, Xi'an, China.
Zhang Z; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiang H; Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang W; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huang J; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen X; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang W; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Oxid Med Cell Longev ; 2021: 4190098, 2021.

Article em En | MEDLINE | ID: mdl-34777686

Assuntos

Doenças das Cartilagens/prevenção & controle; Inflamação/prevenção & controle; NF-kappa B/antagonistas & inibidores; Osteoartrite/complicações; Dor/prevenção & controle; Compostos Fitoquímicos/farmacologia; Receptor 4 Toll-Like/antagonistas & inibidores; Animais; Anti-Inflamatórios/farmacologia; Doenças das Cartilagens/etiologia; Doenças das Cartilagens/metabolismo; Doenças das Cartilagens/patologia; Modelos Animais de Doenças; Inflamação/etiologia; Inflamação/metabolismo; Inflamação/patologia; Masculino; Medicina Tradicional Chinesa; Camundongos; Camundongos Endogâmicos C57BL; Dor/etiologia; Dor/metabolismo; Dor/patologia; Extratos Vegetais/farmacologia; Substâncias Protetoras/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Dor / Doenças das Cartilagens / NF-kappa B / Receptor 4 Toll-Like / Compostos Fitoquímicos / Inflamação Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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