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Alkaloids from Phaeanthus vietnamensis with inhibitory effect on nitric oxide production lipopolysaccharide-stimulated in RAW264.7 macrophages.
Tu, Duong Ngoc; Hau, Vu Thi Bich; Diep, Nguyen Thi; Khanh, Ho Van; Long, Nguyen The; Trang, Ha Thi Huyen; Hoang, Nguyen Huy; Kiem, Phan Van; Nhiem, Nguyen Xuan.
Afiliação
  • Tu DN; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Hau VTB; Department of Science and Technology of Danang, 24 Tran Phu, Danang City 50207, Vietnam.
  • Diep NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Khanh HV; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Long NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Trang HTH; Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi 12116, Vietnam.
  • Hoang NH; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Kiem PV; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
  • Nhiem NX; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi 11307, Vietnam.
J Asian Nat Prod Res ; 24(9): 898-903, 2022 Sep.
Article em En | MEDLINE | ID: mdl-34779313
The chemical study of the acidic extract of Phaeanthus vietnamensis leaves led to the isolation of one new alkaloid, vietnamine A (1) and eight known alkaloids (R,S)-2N-norberbamunine (2), grisabine (3), 1S,1'R,O,O'-dimethylgrisabine (4), dauricine (5), neothalibrine (6), vietnamine (7), xylopine (8), and argentinine (9) by NMR and MS and comparing with the data reported in the literature. Compounds 1-9 were evaluated for inhibitory NO production in RAW 264.7 macrophages, LPS-stimulated. Compounds 1-3 significantly inhibited on NO production with the IC50 values of 6.8 ± 0.9, 9.8 ± 1.0, and 7.1 ± 0.4 µg/ml, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Annonaceae / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Annonaceae / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article