Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells <i>in vitro</i>.

Song, Hong-Yan; Xia, Jing-Sheng; Chen, Yong-Gang; Chen, Ling

Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro.

Song, Hong-Yan; Xia, Jing-Sheng; Chen, Yong-Gang; Chen, Ling.

Afiliação

Song HY; Department of Pharmacy, 12390Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
Xia JS; Department of Pharmacy, 12390Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
Chen YG; Department of Pharmacy, 12390Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
Chen L; Department of Pharmacy, 12390Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.

Hum Exp Toxicol ; 40(12_suppl): S646-S653, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34784831

Assuntos

Antineoplásicos/uso terapêutico; Carcinoma Hepatocelular/tratamento farmacológico; Citocromo P-450 CYP3A/genética; Neoplasias Hepáticas/tratamento farmacológico; Polimorfismo Genético; Sorafenibe/uso terapêutico; Antineoplásicos/farmacocinética; Humanos; Sorafenibe/farmacocinética

Palavras-chave

CYP3A5; hepatocellular carcinoma; metabolism; polymorphisms; sorafenib; sorafenib N-oxide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Carcinoma Hepatocelular / Citocromo P-450 CYP3A / Sorafenibe / Neoplasias Hepáticas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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