Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with <i>Mycobacterium tuberculosis</i>.

Fu, Yan; Shen, Jingjing; Li, Yinhong; Liu, Fanglin; Ning, Bangzuo; Zheng, Yuejuan; Jiang, Xin

Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with Mycobacterium tuberculosis.

Fu, Yan; Shen, Jingjing; Li, Yinhong; Liu, Fanglin; Ning, Bangzuo; Zheng, Yuejuan; Jiang, Xin.

Afiliação

Fu Y; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shen J; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li Y; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu F; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ning B; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zheng Y; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jiang X; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Mediators Inflamm ; 2021: 1805147, 2021.

Article em En | MEDLINE | ID: mdl-34790063

Assuntos

Proteínas de Transporte/antagonistas & inibidores; Flavonoides/farmacologia; Mycobacterium tuberculosis/patogenicidade; Proteína 3 que Contém Domínio de Pirina da Família NLR/antagonistas & inibidores; Piroptose/efeitos dos fármacos; Tiorredoxinas/antagonistas & inibidores; eIF-2 Quinase/antagonistas & inibidores; Animais; Proteínas de Transporte/fisiologia; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Macrófagos/microbiologia; Macrófagos/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Proteína 3 que Contém Domínio de Pirina da Família NLR/fisiologia; Células RAW 264.7; Tiorredoxinas/fisiologia; eIF-2 Quinase/fisiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiorredoxinas / Flavonoides / Proteínas de Transporte / EIF-2 Quinase / Piroptose / Proteína 3 que Contém Domínio de Pirina da Família NLR / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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