Disclosing targets and pharmacological mechanisms of total bioflavonoids extracted from Selaginella doederleinii against non-small cell lung cancer by combination of network pharmacology and proteomics.

Xu, Dafen; Wang, Xuewen; Huang, Dandan; Chen, Bing; Lin, Xinhua; Liu, Ailin; Huang, Jianyong

Xu, Dafen; Wang, Xuewen; Huang, Dandan; Chen, Bing; Lin, Xinhua; Liu, Ailin; Huang, Jianyong.

Afiliação

Xu D; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic
Wang X; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic
Huang D; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic
Chen B; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic
Lin X; Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, China. Electronic address: xhlin1963@sina.com.
Liu A; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic
Huang J; Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for NanoBiomedical Technology of Fujian Province, Fujian Medic

J Ethnopharmacol ; 286: 114836, 2022 Mar 25.

Article em En | MEDLINE | ID: mdl-34793885

Assuntos

Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Flavonoides/farmacologia; Neoplasias Pulmonares/tratamento farmacológico; Selaginellaceae/química; Animais; Antineoplásicos Fitogênicos/isolamento & purificação; Antineoplásicos Fitogênicos/farmacologia; Linhagem Celular Tumoral; Flavonoides/isolamento & purificação; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Simulação de Acoplamento Molecular; Farmacologia em Rede; Fosfatidilinositol 3-Quinase/metabolismo; Proteômica; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Epidermal growth factor receptor; MAPK signaling Pathway; Non-small cell lung cancer; PI3K-AKT signaling Pathway; Total bioï¬avonoids extract of Selaginella doederleinii

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Carcinoma Pulmonar de Células não Pequenas / Selaginellaceae / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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