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Powering on cGAMP mini factories.
Gantier, Michael P.
Afiliação
  • Gantier MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic., Australia.
EMBO Rep ; 23(1): e54231, 2022 01 05.
Article em En | MEDLINE | ID: mdl-34796613
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential innate immune sensor. Remarkably, in addition to its role in the early detection of pathogenic DNA molecules, cGAS also monitors cellular health through the sensing of nuclear and mitochondrial DNA aberrantly localised to the cell cytoplasm. This central position of cGAS requires tight molecular controls which are only starting to be understood. In this issue of EMBO Reports, Zhao and colleagues (Zhao et al, 2021) describe a novel mechanism switching on DNA sensing, relying on the formation of primary condensates of cGAS and GTPase-activating protein-(SH3 domain)-binding protein 1 (G3BP1).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Helicases / RNA Helicases Tipo de estudo: Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Helicases / RNA Helicases Tipo de estudo: Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article