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Energetic scaling in microbial growth.
Calabrese, Salvatore; Chakrawal, Arjun; Manzoni, Stefano; Van Cappellen, Philippe.
Afiliação
  • Calabrese S; Department of Biological and Agricultural Engineering, Texas A&M University, College Station, TX 77843; salvatore.calabrese@ag.tamu.edu.
  • Chakrawal A; Department of Physical Geography, Stockholm University, 106 91 Stockholm, Sweden.
  • Manzoni S; Bolin Centre for Climate Research, Stockholm University, 106 91 Stockholm, Sweden.
  • Van Cappellen P; Department of Physical Geography, Stockholm University, 106 91 Stockholm, Sweden.
Proc Natl Acad Sci U S A ; 118(47)2021 11 23.
Article em En | MEDLINE | ID: mdl-34799445
Microbial growth is a clear example of organization and structure arising in nonequilibrium conditions. Due to the complexity of the microbial metabolic network, elucidating the fundamental principles governing microbial growth remains a challenge. Here, we present a systematic analysis of microbial growth thermodynamics, leveraging an extensive dataset on energy-limited monoculture growth. A consistent thermodynamic framework based on reaction stoichiometry allows us to quantify how much of the available energy microbes can efficiently convert into new biomass while dissipating the remaining energy into the environment and producing entropy. We show that dissipation mechanisms can be linked to the electron donor uptake rate, a fact leading to the central result that the thermodynamic efficiency is related to the electron donor uptake rate by the scaling law [Formula: see text] and to the growth yield by [Formula: see text] These findings allow us to rederive the Pirt equation from a thermodynamic perspective, providing a means to compute its coefficients, as well as a deeper understanding of the relationship between growth rate and yield. Our results provide rather general insights into the relation between mass and energy conversion in microbial growth with potentially wide application, especially in ecology and biotechnology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Termodinâmica / Bactérias / Modelos Biológicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Termodinâmica / Bactérias / Modelos Biológicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article