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Early life stress and susceptibility to addiction in adolescence.
Tschetter, K E; Callahan, L B; Flynn, S A; Rahman, S; Beresford, T P; Ronan, P J.
Afiliação
  • Tschetter KE; Research Service, Sioux Falls VA Healthcare System, Sioux Falls, SD, United States; Department of Psychiatry and Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, United States; Division of Basic Biomedical Sciences, University of South Dakota Sanford
  • Callahan LB; Research Service, Sioux Falls VA Healthcare System, Sioux Falls, SD, United States; Department of Psychiatry and Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, United States; Division of Basic Biomedical Sciences, University of South Dakota Sanford
  • Flynn SA; Department of Psychiatry and Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, United States.
  • Rahman S; Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, United States.
  • Beresford TP; Laboratory for Clinical and Translational Research in Psychiatry, Rocky Mountain Regional, VA Medical Center, Aurora, CO, United States; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, United States.
  • Ronan PJ; Research Service, Sioux Falls VA Healthcare System, Sioux Falls, SD, United States; Department of Psychiatry and Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, United States; Division of Basic Biomedical Sciences, University of South Dakota Sanford
Int Rev Neurobiol ; 161: 277-302, 2022.
Article em En | MEDLINE | ID: mdl-34801172
Early life stress (ELS) is a risk factor for developing a host of psychiatric disorders. Adolescence is a particularly vulnerable period for the onset of these disorders and substance use disorders (SUDs). Here we discuss ELS and its effects in adolescence, especially SUDs, and their correlates with molecular changes to signaling systems in reward and stress neurocircuits. Using a maternal separation (MS) model of neonatal ELS, we studied a range of behaviors that comprise a "drug-seeking" phenotype. We then investigated potential mechanisms underlying the development of this phenotype. Corticotropin releasing factor (CRF) and serotonin (5-HT) are widely believed to be involved in "stress-induced" disorders, including addiction. Here, we show that ELS leads to the development of a drug-seeking phenotype indicative of increased susceptibility to addiction and concomitant sex-dependent upregulation of CRF and 5-HT system components throughout extended brain reward/stress neurocircuits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Relacionados ao Uso de Substâncias / Experiências Adversas da Infância Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Relacionados ao Uso de Substâncias / Experiências Adversas da Infância Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article