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Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata, Nicole; Chaikuad, Apirat; Bakas, Nicole A; Limpert, Allison S; Lambert, Lester J; Sheffler, Douglas J; Berger, Lena M; Liu, Guoxiong; Yuan, Cunxiang; Wang, Li; Peng, Yi; Dong, Jing; Celeridad, Maria; Layng, Fabiana; Knapp, Stefan; Cosford, Nicholas D P.
Afiliação
  • Bata N; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Chaikuad A; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.
  • Bakas NA; Institute for Pharmaceutical Chemistry, Max von Lauestrasse 9, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.
  • Limpert AS; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Lambert LJ; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Sheffler DJ; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Berger LM; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Liu G; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.
  • Yuan C; Institute for Pharmaceutical Chemistry, Max von Lauestrasse 9, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.
  • Wang L; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China.
  • Peng Y; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China.
  • Dong J; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China.
  • Celeridad M; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China.
  • Layng F; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China.
  • Knapp S; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Cosford NDP; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
J Med Chem ; 65(2): 1352-1369, 2022 01 27.
Article em En | MEDLINE | ID: mdl-34807584
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Via de Sinalização Hippo / Serina-Treonina Quinase 3 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Via de Sinalização Hippo / Serina-Treonina Quinase 3 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article