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Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide-trehalose probe based on nitroreductase Rv2466c.
Li, Xueyuan; Geng, Pengfei; Hong, Xiaoqiao; Sun, Zhaogang; Liu, Gang.
Afiliação
  • Li X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Geng P; Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.
  • Hong X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Sun Z; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Liu G; Translational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. sunzg75@163.com.
Chem Commun (Camb) ; 57(97): 13174-13177, 2021 Dec 07.
Article em En | MEDLINE | ID: mdl-34812827
ABSTRACT
A new Mtb fluorescent probe, NFC-Tre-5, was reported that could label single cells of Mtb under various stress conditions via a unique fluorescence off-on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection of Mtb in sputum samples from patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trealose / Nitrorredutases / Piranocumarinas / Corantes Fluorescentes / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trealose / Nitrorredutases / Piranocumarinas / Corantes Fluorescentes / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article