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[Molecular-related epidemic characteristics of influenza A (H3N2) viruses in Guangzhou, 2019].
Cao, L; Wu, D; Chen, Y Y; Zeng, Q; Xia, D; Liu, Y H; Lu, J Y; Li, K B; Di, B; Zhang, Z B.
Afiliação
  • Cao L; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Wu D; Department of Infectious Diseases Prevention and Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Chen YY; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Zeng Q; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Xia D; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Liu YH; Department of Infectious Diseases Prevention and Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Lu JY; Department of Infectious Diseases Prevention and Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Li KB; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Di B; Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
  • Zhang ZB; Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(5): 891-897, 2021 May 10.
Article em Zh | MEDLINE | ID: mdl-34814484
ABSTRACT

Objective:

To isolate the influenza A (H3N2) viruses from different sources in Guangzhou in 2019 and analyze these viruses' evolution and variation characteristics.

Methods:

The hemagglutinin (HA) and neuraminidase (NA) genes of H3N2 isolates from outpatient monitoring, influenza outbreaks, and inpatient severe cases in Guangzhou in 2019 were sequenced. Bioinformatics software analyzed the variations and evolution characteristics of HA and NA genes.

Results:

The epidemic peaks of influenza A (H3N2) viruses were made up of period Ⅰ (from January to August) and period Ⅱ (from November to December). The positive rate of influenza A (H3N2) in males was 13.46% (703/5 221), which was higher than that in females (11.50%, 510/4 435) (χ2=8.43,P=0.00). The group's positive rate of 10-20 years old was the highest (25.18%,665/2 641). The isolates from different sources were highly homologous and closely related to 3C.2a.1 branches, which could be further divided into three small groups of Group 1-3. Gene recombination was observed between different branches. The mutations of HA antigen sites gradually appeared from Group 1 to Group 3, leading to new antigen drift. Variations of HA antigenic sites mainly occurred in the region of A and B. The mutations of receptor binding sites of Group 1 and Group 3 viruses occurred in the anterior and posterior walls. There were two glycosylation sites lacked on region A of HA antigen observed in the isolates of Group 2-3.

Conclusions:

Genetic variations of H3N2 influenza viruses in Guangzhou included gene mutations and gene recombination. Under the pressure of the vaccine, the evolution of viruses was rapid. Therefore, the monitoring of molecular-related epidemic characteristics of the H3N2 influenza virus was necessary.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H3N2 / Epidemias Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Asia Idioma: Zh Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H3N2 / Epidemias Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Asia Idioma: Zh Ano de publicação: 2021 Tipo de documento: Article