Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses.
Nat Commun
; 12(1): 6844, 2021 11 25.
Article
em En
| MEDLINE
| ID: mdl-34824230
ABSTRACT
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Children's non-specific immune profile is dominated by naive lymphocytes and HLA-DRhighCX3CR1low dendritic cells; meanwhile, children show strong specific antibody and T cell responses for viral structural proteins, with their T cell responses differing from adults by having weaker CD8+TNF+ T cells responses to S peptide pool but stronger responses to N and M peptide pools. Finally, viral mRNA is more abundant in pediatric patients. Our data thus support a scenario in which SARS-CoV-2 infected children contribute to transmission yet are less susceptible to COVID-19 symptoms due to strong and differential responses to the virus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Vacinas Sintéticas
/
Imunidade Humoral
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SARS-CoV-2
/
COVID-19
/
Anticorpos Antivirais
Limite:
Adolescent
/
Adult
/
Aged
/
Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article