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Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells.
Hetemäki, Iivo; Kaustio, Meri; Kinnunen, Matias; Heikkilä, Nelli; Keskitalo, Salla; Nowlan, Kirsten; Miettinen, Simo; Sarkkinen, Joona; Glumoff, Virpi; Andersson, Noora; Kettunen, Kaisa; Vanhanen, Reetta; Nurmi, Katariina; Eklund, Kari K; Dunkel, Johannes; Mäyränpää, Mikko I; Schlums, Heinrich; Arstila, T Petteri; Kisand, Kai; Bryceson, Yenan T; Peterson, Pärt; Otava, Ulla; Syrjänen, Jaana; Saarela, Janna; Varjosalo, Markku; Kekäläinen, Eliisa.
Afiliação
  • Hetemäki I; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kaustio M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Kinnunen M; Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Heikkilä N; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Keskitalo S; Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Nowlan K; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Miettinen S; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Sarkkinen J; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Glumoff V; Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
  • Andersson N; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kettunen K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Vanhanen R; Department of Clinical Genetics and HUSLAB Laboratory of Genetics, Helsinki University Hospital, Helsinki, Finland.
  • Nurmi K; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Eklund KK; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Dunkel J; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Mäyränpää MI; Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Schlums H; Orton Orthopaedic Hospital of the Orton Foundation, Helsinki, Finland.
  • Arstila TP; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kisand K; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Bryceson YT; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Peterson P; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Otava U; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
  • Syrjänen J; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Saarela J; Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway.
  • Varjosalo M; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
  • Kekäläinen E; Infectious Disease Unit, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Sci Immunol ; 6(65): eabe3454, 2021 Nov 26.
Article em En | MEDLINE | ID: mdl-34826260
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Transcrição Ikaros / Células T Invariantes Associadas à Mucosa Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Transcrição Ikaros / Células T Invariantes Associadas à Mucosa Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article