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Microglia and Astrocytes in Alzheimer's Disease in the Context of the Aberrant Copper Homeostasis Hypothesis.
Pal, Amit; Rani, Isha; Pawar, Anil; Picozza, Mario; Rongioletti, Mauro; Squitti, Rosanna.
Afiliação
  • Pal A; Department of Biochemistry, AIIMS, Kalyani 741245, West Bengal, India.
  • Rani I; Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Maharishi Markandeshwar University (MMU), Mullana, Ambala 133207, Haryana, India.
  • Pawar A; Department of Zoology, DAV University, Jalandhar 144012, Punjab, India.
  • Picozza M; Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, 00143 Rome, Italy.
  • Rongioletti M; Department of Laboratory Medicine, Research and Development Division, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, 00186 Rome, Italy.
  • Squitti R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Biomolecules ; 11(11)2021 10 28.
Article em En | MEDLINE | ID: mdl-34827595
Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Microglia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Microglia Idioma: En Ano de publicação: 2021 Tipo de documento: Article