Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation.
Int J Mol Sci
; 22(22)2021 Nov 12.
Article
em En
| MEDLINE
| ID: mdl-34830152
ABSTRACT
Phase-separated condensates participate in various biological activities. Liquid-liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin-with various morphologies and activities-is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Ciclo Celular
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Cromossomos de Mamíferos
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Montagem e Desmontagem da Cromatina
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Proteínas de Ligação a DNA
/
Proteínas Intrinsicamente Desordenadas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article