SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism.

Kumar, Nitin; Zuo, Yu; Yalavarthi, Srilakshmi; Hunker, Kristina L; Knight, Jason S; Kanthi, Yogendra; Obi, Andrea T; Ganesh, Santhi K

Kumar, Nitin; Zuo, Yu; Yalavarthi, Srilakshmi; Hunker, Kristina L; Knight, Jason S; Kanthi, Yogendra; Obi, Andrea T; Ganesh, Santhi K.

Afiliação

Kumar N; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Zuo Y; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Yalavarthi S; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA.
Hunker KL; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA.
Knight JS; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kanthi Y; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Obi AT; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA.
Ganesh SK; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Viruses ; 13(11)2021 11 03.

Article em En | MEDLINE | ID: mdl-34835015

Assuntos

COVID-19/patologia; Di-Hidrotestosterona/farmacologia; Endotélio Vascular/patologia; Inflamação; SARS-CoV-2/fisiologia; Glicoproteína da Espícula de Coronavírus/fisiologia; Espironolactona/farmacologia; Antagonistas de Receptores de Angiotensina/farmacologia; COVID-19/fisiopatologia; COVID-19/virologia; Moléculas de Adesão Celular/sangue; Células Cultivadas; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/metabolismo; Feminino; Humanos; Masculino; Caracteres Sexuais; Fator de Necrose Tumoral alfa/farmacologia; Fator de Necrose Tumoral alfa/fisiologia; Valsartana/farmacologia

Palavras-chave

COVID-19; E-selectin; androgen; angiotensin receptor blocker; endothelial injury; spironolactone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espironolactona / Di-Hidrotestosterona / Endotélio Vascular / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Inflamação Limite: Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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