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MRI guided focused ultrasound (MRgFUS) treatment for uterine fibroids among women with and without abdominal scars.
Inbar, Yael; Machtinger, Ronit; Barnett-Itzhaki, Zohar; Goldblatt, Avishai; Stoler, Eti; Rabinovici, Jaron.
Afiliação
  • Inbar Y; Departments of Radiology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Machtinger R; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Barnett-Itzhaki Z; Advanced Technology Center, Sheba Medical Center, Tel-Hashomer, Israel.
  • Goldblatt A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Stoler E; Advanced Technology Center, Sheba Medical Center, Tel-Hashomer, Israel.
  • Rabinovici J; Departments of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
Int J Hyperthermia ; 38(1): 1672-1676, 2021.
Article em En | MEDLINE | ID: mdl-34843654
ABSTRACT

INTRODUCTION:

MRI guided focused ultrasound (MRgFUS) is a noninvasive technique for treating uterine fibroids. The presence of abdominal scars can limit the number of women eligible for the procedure, due to absorbance of beam energy. The goals of this study were to assess the number of women that fit the procedure and to compare outcomes among women with or without abdominal scars. MATERIAL AND

METHODS:

A prospective cohort study of all women that were interested in MRgFUS in a single University-Affiliated Hospital between November 2012 and December 2019. Rates of women that were referred to further screening, fulfilled selection criteria and underwent the procedure were compared between patients with or without abdominal scars. We evaluated the treatment parameters of the two groups and used linear regression model predict non-perfused volume (NPV) at the end of the process.

RESULTS:

Out of 701 patients, 21.8% were suitable for MRgFUS. Women with scars had significant lower NPV compared with women without scars (60% versus 82.4%, p = 0.021). No serious adverse events were reported in both groups. Linear regression models showed that fibroids' volume, stopping the treatment due to severe pain and the presence of abdominal scars had a statistically significantly negative effect on NPV (betas -11.51, -6.96, and -6.29, p-values <0.001, 0.003, and 0.007 respectively), while number of sonication had a statistically significantly positive effect on NPV (beta = 5.98, p = 0.011).

CONCLUSION:

Regardless of strict inclusion criteria, MRgFUS treatment is less efficient among women with abdominal scars, although still feasible for those who are interested in noninvasive option.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Ablação por Ultrassom Focalizado de Alta Intensidade / Leiomioma Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Ablação por Ultrassom Focalizado de Alta Intensidade / Leiomioma Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article