Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells.

Piven, Yuri A; Yastrebova, Margarita A; Khamidullina, Alvina I; Scherbakov, Alexander M; Tatarskiy, Victor V; Rusanova, Julia A; Baranovsky, Alexander V; Zinovich, Veronica G; Khlebnicova, Tatyana S; Lakhvich, Fedor A

Piven, Yuri A; Yastrebova, Margarita A; Khamidullina, Alvina I; Scherbakov, Alexander M; Tatarskiy, Victor V; Rusanova, Julia A; Baranovsky, Alexander V; Zinovich, Veronica G; Khlebnicova, Tatyana S; Lakhvich, Fedor A.

Afiliação

Piven YA; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Akad. Kuprevicha st. 5/2, Minsk 220141, Belarus.
Yastrebova MA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Vavilova st. 34/5, Moscow 119334, Russian Federation.
Khamidullina AI; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Vavilova st. 34/5, Moscow 119334, Russian Federation.
Scherbakov AM; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye sh. 24, Moscow 115522, Russian Federation.
Tatarskiy VV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Vavilova st. 34/5, Moscow 119334, Russian Federation.
Rusanova JA; Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska str., Kyiv 01601, Ukraine.
Baranovsky AV; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Akad. Kuprevicha st. 5/2, Minsk 220141, Belarus.
Zinovich VG; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Akad. Kuprevicha st. 5/2, Minsk 220141, Belarus.
Khlebnicova TS; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Akad. Kuprevicha st. 5/2, Minsk 220141, Belarus.
Lakhvich FA; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Akad. Kuprevicha st. 5/2, Minsk 220141, Belarus.

Bioorg Med Chem ; 53: 116521, 2022 01 01.

Article em En | MEDLINE | ID: mdl-34844036

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Proteínas de Choque Térmico HSP90/antagonistas & inibidores; Oxazóis/farmacologia; Oximas/farmacologia; Acilação; Antineoplásicos/síntese química; Antineoplásicos/química; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Cristalografia por Raios X; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Modelos Moleculares; Estrutura Molecular; Oxazóis/síntese química; Oxazóis/química; Oximas/síntese química; Oximas/química; Relação Estrutura-Atividade

Palavras-chave

Antiproliferative activity; Apoptosis; Benzisoxazoles; Breast cancer; Docking; HER2/neu (ERBB2); HSP90; O-acyloximes; Virtual screening

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazóis / Oximas / Neoplasias da Mama / Proteínas de Choque Térmico HSP90 / Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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