The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3.

Okalang, Uthman; Mualem Bar-Ner, Bar; Rajan, K Shanmugha; Friedman, Nehemya; Aryal, Saurav; Egarmina, Katarina; Hope, Ronen; Khazanov, Netaly; Senderowitz, Hanoch; Alon, Assaf; Fass, Deborah; Michaeli, Shulamit

Okalang, Uthman; Mualem Bar-Ner, Bar; Rajan, K Shanmugha; Friedman, Nehemya; Aryal, Saurav; Egarmina, Katarina; Hope, Ronen; Khazanov, Netaly; Senderowitz, Hanoch; Alon, Assaf; Fass, Deborah; Michaeli, Shulamit.

Afiliação

Okalang U; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Mualem Bar-Ner B; Department of Biochemistry and Molecular Biology, Busitema University, Mbale, Uganda.
Rajan KS; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Friedman N; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Aryal S; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Egarmina K; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Hope R; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Khazanov N; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Senderowitz H; Chemistry Department, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Alon A; Chemistry Department, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Fass D; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Michaeli S; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

mBio ; 12(6): e0260221, 2021 12 21.

Article em En | MEDLINE | ID: mdl-34844425

Assuntos

Retículo Endoplasmático/metabolismo; Complexo de Golgi/metabolismo; Proteínas Mitocondriais/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas de Protozoários/metabolismo; RNA de Protozoário/genética; RNA Líder para Processamento/genética; Trypanosoma brucei brucei/genética; Tripanossomíase Africana/parasitologia; Núcleo Celular/genética; Núcleo Celular/metabolismo; Retículo Endoplasmático/genética; Complexo de Golgi/genética; Humanos; Proteínas Mitocondriais/genética; Proteínas Serina-Treonina Quinases/genética; Transporte Proteico; Proteínas de Protozoários/genética; Interferência de RNA; Splicing de RNA; RNA de Protozoário/metabolismo; RNA Líder para Processamento/metabolismo; Proteína de Ligação a TATA-Box/genética; Proteína de Ligação a TATA-Box/metabolismo; Trypanosoma brucei brucei/enzimologia; Trypanosoma brucei brucei/metabolismo

Palavras-chave

BiP; ERO1; PK3-PERK homologue; QSOX; SLS; TIMRHOM1; calreticulin; spliced leader RNA silencing; trypanosomes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma brucei brucei / Tripanossomíase Africana / Proteínas de Protozoários / RNA de Protozoário / Proteínas Serina-Treonina Quinases / RNA Líder para Processamento / Proteínas Mitocondriais / Retículo Endoplasmático / Complexo de Golgi Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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