Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5'-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species.

Kuwagata, Makiko; Hasegawa, Takuro; Takashima, Hiromasa; Shimizu, Makiko; Kitajima, Satoshi; Yamazaki, Hiroshi

Kuwagata, Makiko; Hasegawa, Takuro; Takashima, Hiromasa; Shimizu, Makiko; Kitajima, Satoshi; Yamazaki, Hiroshi.

Afiliação

Kuwagata M; Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences.
Hasegawa T; Tsukuba Laboratory, BoZo Research Center.
Takashima H; Gotemba Laboratory, BoZo Research Center.
Shimizu M; Showa Pharmaceutical University.
Kitajima S; Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences.
Yamazaki H; Showa Pharmaceutical University.

J Toxicol Sci ; 46(12): 553-560, 2021.

Article em En | MEDLINE | ID: mdl-34853241

Assuntos

Fígado; Talidomida; Administração Oral; Animais; Masculino; Camundongos; Coelhos; Talidomida/análogos & derivados; Talidomida/toxicidade

Palavras-chave

5-Hydroxythalidomide; Human; PBPK modeling; Seminal plasma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talidomida / Fígado Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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