Development of Novel Methodology Using Diazo Compounds and Metal Catalysts.
Chem Pharm Bull (Tokyo)
; 69(12): 1170-1178, 2021.
Article
em En
| MEDLINE
| ID: mdl-34853283
The ability to control the reactions of highly active chemical species to enable straightforward synthesis of valuable compounds such as bioactive natural products and pharmaceuticals is a continuing challenge in synthetic organic chemistry. This review describes the development of a methodology using reactive metal-carbene species and its synthetic application in our laboratory. First, regioselective synthesis of γ-amino acid equivalents to take advantage of their metal-dependent reactivities and the mechanistic rationale are presented. Chemoselective and enantioselective dearomatization reactions of several arenes with silver-carbene are also discussed. In the second half of the review, we discuss a carbene-insertion reaction into an amide and urea C-N bond for the assembly of nitrogen-bridged cyclic molecules.
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01-internacional
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MEDLINE
Assunto principal:
Compostos Azo
/
Metais Pesados
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article