A new translocation, t(10;14)(q24;q11), in T cell neoplasia.
Blood
; 67(4): 1181-4, 1986 Apr.
Article
em En
| MEDLINE
| ID: mdl-3485458
ABSTRACT
Four cases of T cell neoplasia are reported three presenting as T cell acute lymphoblastic leukemia and one presenting in the leukemic phase of a T cell lymphoma. In all cases, the cells of the leukemic clone were characterized by an identical cytogenetic abnormality. This abnormality was a unique reciprocal translocation involving chromosomes 10 and 14. The breakpoint in chromosome 14 was in band q11, coincident with the assigned locus of the alpha-chain gene of the T cell antigen receptor. The breakpoint in chromosome 10 was in band q24, a region reported to include the locus of the terminal deoxynucleotidyltransferase (TdT) gene. Our observations suggest that translocation t(10;14)(q24;q11) is specific for T cell neoplasia and that a gene in chromosomal band 10q24, possibly the TdT gene, plays an important role in T cell neoplasia when its expression or coding sequence is altered by aberrant recombination involving a T cell antigen receptor gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Linfócitos T
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Leucemia Linfoide
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Cromossomos Humanos 13-15
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Cromossomos Humanos 6-12 e X
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Linfoma
Limite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article