Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus.
Biochem Biophys Res Commun
; 587: 63-68, 2022 01 08.
Article
em En
| MEDLINE
| ID: mdl-34864548
ABSTRACT
The concept of tRNA recycling has recently emerged from the studies of ribosome-associated quality control. Therein tRNase ZS removes the 2', 3'>p from the ANKZF1-cleaved tRNA and the subsequent TRNT1 action re-generates the intact tRNA. To know the roles of the tRNA recycling in vivo, we investigated how viral infection affects the tRNA recycling system by analyzing the mRNA levels of tRNase ZS and TRNT1. We found that both genes in HeLa cells are upregulated in response to infection of Theiler's mouse encephalitis virus but not to that of an influenza A virus. Upregulation was also observed in cells infected with encephalomyocarditis virus with reduced efficiency. The levels of the IFN-ß mRNA appeared to positively correlate with those of the tRNase ZS and TRNT1 mRNAs. The tRNase ZS gene may be regulated post-transcriptionally in the cells infected with Theiler's mouse encephalitis virus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA de Transferência
/
Processamento Pós-Transcricional do RNA
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Theilovirus
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Endorribonucleases
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Interações Hospedeiro-Patógeno
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Nucleotidiltransferases
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article