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Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD.
Hyun, Jae-Won; Lee, Hye Lim; Park, Jaehong; Kim, Jiah; Min, Ju-Hong; Kim, Byoung Joon; Kim, Seung Woo; Shin, Ha Young; Huh, So-Young; Kim, Woojun; Seo, Ji Won; Kim, Ki Hoon; Kim, Su-Hyun; Kim, Ho Jin.
Afiliação
  • Hyun JW; Department of Neurology, National Cancer Center, Goyang, Korea.
  • Lee HL; Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea.
  • Park J; Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • Kim J; Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • Min JH; Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • Kim BJ; Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • Kim SW; College of Medicine, Yonsei University, Seoul, Korea.
  • Shin HY; College of Medicine, Yonsei University, Seoul, Korea.
  • Huh SY; College of Medicine, Kosin University, Busan, Korea.
  • Kim W; The Catholic University of Korea, Seoul, Korea.
  • Seo JW; Department of Radiology, National Cancer Center, Goyang, Korea.
  • Kim KH; Department of Neurology, National Cancer Center, Goyang, Korea.
  • Kim SH; Department of Neurology, National Cancer Center, Goyang, Korea.
  • Kim HJ; Department of Neurology, National Cancer Center, Goyang, Korea.
Mult Scler ; 28(6): 989-992, 2022 05.
Article em En | MEDLINE | ID: mdl-34865555
ABSTRACT
In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)-using the refined terminology-on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuromielite Óptica / Aquaporina 4 Tipo de estudo: Observational_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuromielite Óptica / Aquaporina 4 Tipo de estudo: Observational_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article