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Triterpenoids of Rhus chinensis Supressed Colorectal Cancer Progress by Enhancing Antitumor Immunity and CD8 + T Cells Tumor Infiltration.
Wang, Gang; Yu, Yang; Li, Zi-Meng; Zhu, Zhi-Min; Wang, Zhi-Jie; Tao, Min-Fang.
Afiliação
  • Wang G; Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China.
  • Yu Y; Department of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
  • Li ZM; Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China.
  • Zhu ZM; Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China.
  • Wang ZJ; Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China.
  • Tao MF; Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China.
Nutr Cancer ; 74(7): 2550-2564, 2022.
Article em En | MEDLINE | ID: mdl-34866510
ABSTRACT
The absence of CD8+ T cells in the tumor center has become a major obstacle in the immunotherapy of colorectal cancer. Therefore, new therapeutic strategies are urgently needed to promote the accumulation of CD8+ T cells in the tumor center. Previous studies have shown that triterpenoid of Rhus chinensis (TER) is involved in the proliferation and apoptosis of colorectal cancer cells, and can regulate their immune activity, but its mechanism needs to be further elucidated. In this study, the antitumor effect and adaptive immune response of TER on tumor-bearing mice were evaluated and compared with 5-fluorouracil. The results showed that TER could significantly inhibit tumor growth and prolong the survival time of tumor-bearing mice. The In Vivo studies have shown that TER can not only enhance antitumor immunity and promote the accumulation of CD8 + T cells to tumor sites, but also inhibit tumor progression by regulating the expression of PD-1 and PD-L1 and significantly reducing the mortality of mice. Our study demonstrated for the first time that TER has oncolytic effect, and recruited adaptive immune cells to enhance the efficacy of anti-PD-1/PD-L1 in colorectal cancer, which provides a potential therapeutic target for combined immunotherapy of colorectal cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Neoplasias Colorretais / Rhus Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Neoplasias Colorretais / Rhus Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article