Cyproterone Acetate-Induced Acute Liver Failure: A Case Report and Review of the Literature.

Kumar, Pramod; Reddy, Sujith; Kulkarni, Anand; Sharma, Mithun; Rao, Padaki N

Kumar, Pramod; Reddy, Sujith; Kulkarni, Anand; Sharma, Mithun; Rao, Padaki N.

Afiliação

Kumar P; Department of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology Hospitals, Survey No 136, Mindspace Rd, Gachibowli, Hyderabad, Telangana 50003, India.
Reddy S; Department of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology Hospitals, Survey No 136, Mindspace Rd, Gachibowli, Hyderabad, Telangana 50003, India.
Kulkarni A; Department of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology Hospitals, Survey No 136, Mindspace Rd, Gachibowli, Hyderabad, Telangana 50003, India.
Sharma M; Department of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology Hospitals, Survey No 136, Mindspace Rd, Gachibowli, Hyderabad, Telangana 50003, India.
Rao PN; Department of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology Hospitals, Survey No 136, Mindspace Rd, Gachibowli, Hyderabad, Telangana 50003, India.

J Clin Exp Hepatol ; 11(6): 739-741, 2021.

Article em En | MEDLINE | ID: mdl-34866850

RESUMO

Cyproterone acetate (CPA), a hydroxyprogesterone derivative, is used to treat advanced prostate cancer and infrequently in women for acne, breast cancer and hirsutism. Transient mild elevation in levels of liver enzymes is reported in 10-30% of patients, and acute liver failure (ALF) is uncommon. Here, we discuss the first case of CPA-induced ALF from India and the available literature.

Palavras-chave

ALF, Acute liver failure; ALT, Alanine transaminase; CPA, Cyproterone acetate; DILI, Drug-induced liver injury; HAV, Hepatitis A virus; HBsAg, Hepatitis B surface antigen; HCV, Hepatitis C virus; HEV, Hepatitis E virus; MELD, Model for end-stage liver disease; RUCAM, Roussel Uclaf Causality Assessment Method; acute liver failure; cyproterone acetate; drug-induced liver injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article