A ß-hairpin peptide with pH-controlled affinity for tumor cells.

Nishimura, Shin-Nosuke; Nishida, Kei; Tanaka, Masaru

Nishimura, Shin-Nosuke; Nishida, Kei; Tanaka, Masaru.

Afiliação

Nishimura SN; Institute for Materials Chemistry and Engineering, Kyushu University, 744, Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan. shinnosuke_nishimura@ms.ifoc.kyushu-u.ac.jp.
Nishida K; Institute for Materials Chemistry and Engineering, Kyushu University, 744, Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan. shinnosuke_nishimura@ms.ifoc.kyushu-u.ac.jp.
Tanaka M; Institute for Materials Chemistry and Engineering, Kyushu University, 744, Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan. shinnosuke_nishimura@ms.ifoc.kyushu-u.ac.jp.

Chem Commun (Camb) ; 58(4): 505-508, 2022 Jan 06.

Article em En | MEDLINE | ID: mdl-34874387

ABSTRACT

ABSTRACT

Considering that the pH in the tumor microenvironment is dysregulated, we designed a ß-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.

Assuntos

Neoplasias/química; Peptídeos/química; Humanos; Concentração de Íons de Hidrogênio; Neoplasias/patologia; Conformação Proteica; Microambiente Tumoral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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