A ß-hairpin peptide with pH-controlled affinity for tumor cells.
Chem Commun (Camb)
; 58(4): 505-508, 2022 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-34874387
ABSTRACT
Considering that the pH in the tumor microenvironment is dysregulated, we designed a ß-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article