New hydroperoxycycloartane-complete chemical shifts assignment of 13C and 1H-and cytotoxicity evaluation of cycloartanes isolated from Trichilia casaretti.
Nat Prod Res
; 36(21): 5423-5428, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-34881656
ABSTRACT
New cycloartane, 22-hydroxy-25-hydroperoxycycloart-23E-en-3-one (1), along with six known analogues (2-7) and three steroids (8-10), were isolated from the leaves of Trichilia casaretti. Structures were elucidated mainly on the basis of the analysis of 1D and 2D NMR (1H and 13C) and HRESIMS spectroscopic data, involving comparison with data of the literature. The cytotoxic activities of 1-7 and 10 isolated compounds were also evaluated against human leukemia cell line Molt-4 (acute lymphoblastic) and exhibited good cytotoxic activity with IC50 values ranging from 10.62 to 21.14 µM.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Meliaceae
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Limoninas
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article