(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.

Chen, Chen; Wang, Yu-Shi; Zhang, En-Ting; Li, Gang-Ao; Liu, Wen-Yuan; Li, Yang; Jin, Ying-Hua

Chen, Chen; Wang, Yu-Shi; Zhang, En-Ting; Li, Gang-Ao; Liu, Wen-Yuan; Li, Yang; Jin, Ying-Hua.

Afiliação

Chen C; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Wang YS; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhang ET; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Li GA; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Liu WY; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Li Y; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Jin YH; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.

Int J Mol Sci ; 22(23)2021 Dec 06.

Article em En | MEDLINE | ID: mdl-34884975

Assuntos

Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/tratamento farmacológico; Proteínas de Ciclo Celular/metabolismo; Chaperoninas/metabolismo; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Ginsenosídeos/farmacologia; Proteínas de Choque Térmico HSP90/metabolismo; Neoplasias Hepáticas/tratamento farmacológico; Apoptose; Biomarcadores Tumorais/genética; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Ciclo Celular; Proteínas de Ciclo Celular/genética; Proliferação de Células; Chaperoninas/genética; Proteínas de Choque Térmico HSP90/genética; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Células Tumorais Cultivadas

Palavras-chave

(20S) G-Rh2; Cdc37; HSP90A; autophagy; human liver cancer; phage display; proteasome degradation pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Proteínas de Choque Térmico HSP90 / Chaperoninas / Proteínas de Ciclo Celular / Ginsenosídeos / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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