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dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project.
Ogishima, Soichi; Nagaie, Satoshi; Mizuno, Satoshi; Ishiwata, Ryosuke; Iida, Keita; Shimokawa, Kazuro; Takai-Igarashi, Takako; Nakamura, Naoki; Nagase, Sachiko; Nakamura, Tomohiro; Tsuchiya, Naho; Nakaya, Naoki; Murakami, Keiko; Ueno, Fumihiko; Onuma, Tomomi; Ishikuro, Mami; Obara, Taku; Mugikura, Shunji; Tomita, Hiroaki; Uruno, Akira; Kobayashi, Tomoko; Tsuboi, Akito; Tadaka, Shu; Katsuoka, Fumiki; Narita, Akira; Sakurai, Mika; Makino, Satoshi; Tamiya, Gen; Aoki, Yuichi; Shimizu, Ritsuko; Motoike, Ikuko N; Koshiba, Seizo; Minegishi, Naoko; Kumada, Kazuki; Nobukuni, Takahiro; Suzuki, Kichiya; Danjoh, Inaho; Nagami, Fuji; Tanno, Kozo; Ohmomo, Hideki; Asahi, Koichi; Shimizu, Atsushi; Hozawa, Atsushi; Kuriyama, Shinichi; Fuse, Nobuo; Tominaga, Teiji; Kure, Shigeo; Yaegashi, Nobuo; Kinoshita, Kengo; Sasaki, Makoto.
Afiliação
  • Ogishima S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
  • Nagaie S; Graduate School of Medicine, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
  • Mizuno S; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
  • Ishiwata R; Tohoku University Hospital, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
  • Iida K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Shimokawa K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Takai-Igarashi T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nakamura N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nagase S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nakamura T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tsuchiya N; Tohoku University Hospital, Tohoku University, Sendai, Japan.
  • Nakaya N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Murakami K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Ueno F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Onuma T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Ishikuro M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Obara T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Mugikura S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tomita H; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Uruno A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kobayashi T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tsuboi A; Graduate School of Medicine, Tohoku University, Sendai, Japan.
  • Tadaka S; Tohoku University Hospital, Tohoku University, Sendai, Japan.
  • Katsuoka F; International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
  • Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Sakurai M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Makino S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Aoki Y; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Shimizu R; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
  • Motoike IN; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Koshiba S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Minegishi N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kumada K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nobukuni T; Graduate School of Medicine, Tohoku University, Sendai, Japan.
  • Suzuki K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Danjoh I; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nagami F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tanno K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Ohmomo H; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
  • Asahi K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Shimizu A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Hozawa A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kuriyama S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Fuse N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tominaga T; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Morioka, Japan.
  • Kure S; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Morioka, Japan.
  • Yaegashi N; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Morioka, Japan.
  • Kinoshita K; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Morioka, Japan.
  • Sasaki M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Hum Genome Var ; 8(1): 44, 2021 Dec 10.
Article em En | MEDLINE | ID: mdl-34887386
ABSTRACT
To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article