Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit &#945;-amylase over &#945;-glucosidases via the incorporation of caffeine acid and its derivatives.

Chen, Wenming; Zhou, Cui; Chen, Jiansheng; Wang, Meizhu; Zhou, Fang; Wang, Chunmei; Zhang, Xu; Zhou, Wen

Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives.

Chen, Wenming; Zhou, Cui; Chen, Jiansheng; Wang, Meizhu; Zhou, Fang; Wang, Chunmei; Zhang, Xu; Zhou, Wen.

Afiliação

Chen W; Department of Pharmaceutical Production Center ï¼ TCM and Ethnomedicine Development International Laboratory, The First Hospital of Hunan University of Chinese Medicine, 95, Shaoshan Rd, Changsha, Hunan 410007, China.
Zhou C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 200241 Shanghai, China; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, University Town, Waihuan Rd., Panyu, Guangzhou 510006, China.
Chen J; College of Forestry and Landscape Architecture, South China Agricultural University, 510642, China.
Wang M; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, University Town, Waihuan Rd., Panyu, Guangzhou 510006, China.
Zhou F; Department of Pharmaceutical Production Center ï¼ TCM and Ethnomedicine Development International Laboratory, The First Hospital of Hunan University of Chinese Medicine, 95, Shaoshan Rd, Changsha, Hunan 410007, China.
Wang C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 200241 Shanghai, China; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural, Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shang
Zhang X; College of Forestry and Landscape Architecture, South China Agricultural University, 510642, China. Electronic address: zhangxu@126.com.
Zhou W; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 200241 Shanghai, China; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural, Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shang

Bioorg Chem ; 119: 105515, 2022 02.

Article em En | MEDLINE | ID: mdl-34896919

Assuntos

Ácidos Cafeicos/farmacologia; Catequina/análogos & derivados; Inibidores de Glicosídeo Hidrolases/farmacologia; Hipoglicemiantes/farmacologia; alfa-Amilases/antagonistas & inibidores; alfa-Glucosidases/metabolismo; Ácidos Cafeicos/síntese química; Ácidos Cafeicos/química; Catequina/síntese química; Catequina/química; Catequina/farmacologia; Diabetes Mellitus/tratamento farmacológico; Diabetes Mellitus/metabolismo; Relação Dose-Resposta a Droga; Desenho de Fármacos; Inibidores de Glicosídeo Hidrolases/síntese química; Inibidores de Glicosídeo Hidrolases/química; Humanos; Hipoglicemiantes/síntese química; Hipoglicemiantes/química; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade; alfa-Amilases/metabolismo

Palavras-chave

Antidiabetic drug; Caffeic acid; EGC; HPA inhibitors; Selectivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Cafeicos / Catequina / Alfa-Amilases / Alfa-Glucosidases / Inibidores de Glicosídeo Hidrolases / Hipoglicemiantes Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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