Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators.

Qiu, Yuran; Wang, Yuanhao; Chai, Zongtao; Ni, Duan; Li, Xinyi; Pu, Jun; Chen, Jie; Zhang, Jian; Lu, Shaoyong; Lv, Chuan; Ji, Mingfei

Qiu, Yuran; Wang, Yuanhao; Chai, Zongtao; Ni, Duan; Li, Xinyi; Pu, Jun; Chen, Jie; Zhang, Jian; Lu, Shaoyong; Lv, Chuan; Ji, Mingfei.

Afiliação

Qiu Y; Department of Urology, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.
Wang Y; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Chai Z; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Ni D; Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Li X; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Pu J; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Chen J; Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200120, China.
Zhang J; Department of Urology, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.
Lu S; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Lv C; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
Ji M; Department of Plastic Surgery, Changhai Hospital, Naval Military Medical University, Shanghai 200438, China.

Acta Pharm Sin B ; 11(11): 3433-3446, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34900528

Palavras-chave

ABL, Abelson; APC, adenomatous polyposis coli; Allostery; CK1, casein kinase 1; CML, chronic myeloid leukemia; ER, endoplasmic reticulum; GAPs, GTPase-activating proteins; GEFs, guanine nucleotide exchange-factors; GSK3, glycogen synthase kinase 3; HVR, hypervariable region; IP3R, inositol trisphosphate receptors; LRP6, lipoprotein-receptor-related protein 6; OMM, outer mitochondrial membrane; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; PPIs, protein−protein interactions; Phosphorylation; Protein kinases; RAS; RIN1, RAB-interacting protein 1; SHP2, SRC homology 2 domain containing phosphatase 2; SOS, Son of Sevenless; STK19, serine/threonine-protein kinase 19; TKIs, tyrosine kinase inhibitors; Undruggable

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article