Irinotecan/scFv co-loaded liposomes coaction on tumor cells and CAFs for enhanced colorectal cancer therapy.

Li, Zhaohuan; Liu, Chunxi; Li, Chenglei; Wang, Fangqing; Liu, Jianhao; Zheng, Zengjuan; Wu, Jingliang; Zhang, Bo

Li, Zhaohuan; Liu, Chunxi; Li, Chenglei; Wang, Fangqing; Liu, Jianhao; Zheng, Zengjuan; Wu, Jingliang; Zhang, Bo.

Afiliação

Li Z; School of Pharmacy, Weifang Medical University Weifang, Shandong, 261053, People's Republic of China.
Liu C; Department of Pharmacy, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, People's Republic of China.
Li C; School of Pharmacy, Weifang Medical University Weifang, Shandong, 261053, People's Republic of China.
Wang F; School of Bioscience and Technology, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Liu J; School of Pharmacy, Weifang Medical University Weifang, Shandong, 261053, People's Republic of China.
Zheng Z; School of Pharmacy, Weifang Medical University Weifang, Shandong, 261053, People's Republic of China.
Wu J; School of Bioscience and Technology, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China. jlwu2008@163.com.
Zhang B; School of Pharmacy, Weifang Medical University Weifang, Shandong, 261053, People's Republic of China. zhangbo@wfmc.edu.cn.

J Nanobiotechnology ; 19(1): 421, 2021 Dec 14.

Article em En | MEDLINE | ID: mdl-34906155

Assuntos

Fibroblastos Associados a Câncer/efeitos dos fármacos; Neoplasias Colorretais/metabolismo; Sistemas de Liberação de Medicamentos/métodos; Irinotecano; Lipossomos; Animais; Antineoplásicos/química; Antineoplásicos/farmacocinética; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Técnicas de Cocultura; Neoplasias Colorretais/patologia; Feminino; Irinotecano/química; Irinotecano/farmacocinética; Irinotecano/farmacologia; Lipossomos/química; Lipossomos/farmacocinética; Lipossomos/farmacologia; Camundongos; Camundongos Endogâmicos BALB C; Células NIH 3T3; Anticorpos de Cadeia Única/química; Anticorpos de Cadeia Única/farmacocinética

Palavras-chave

Cancer-associated fibroblasts; Co-cultured cells; Colorectal cancer; Liposomes; Single chain fragment variable

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Sistemas de Liberação de Medicamentos / Fibroblastos Associados a Câncer / Irinotecano / Lipossomos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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