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Effects of synthetic cathinone naphyrone in the conditioned place preference test - Evidence of its addictive potential.
Danda, Hynek; Pinterová-Leca, Nikola; Síchová, Klára; Stefková-Mazochová, Kristýna; Syrová, Katerina; Olejníková, Lucie; Koncická, Markéta; Mazoch, Vladimír; Lhotková, Eva; Kuchar, Martin; Pálenícek, Tomás.
Afiliação
  • Danda H; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic; 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10 100 00, Czech Republic.
  • Pinterová-Leca N; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic; 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10 100 00, Czech Republic.
  • Síchová K; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Stefková-Mazochová K; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Syrová K; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic; 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10 100 00, Czech Republic.
  • Olejníková L; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Koncická M; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Mazoch V; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Lhotková E; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic.
  • Kuchar M; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic; Forensic Laboratory of Biologically Active Compounds, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Technická 5, Prague 6 166 28, Czech Republic.
  • Pálenícek T; National Institute of Mental Health, Topolová 748, Klecany 250 67, Czech Republic; 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10 100 00, Czech Republic. Electronic address: tomas.palenicek@nudz.cz.
Behav Brain Res ; 421: 113713, 2022 03 12.
Article em En | MEDLINE | ID: mdl-34906607
Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalerone structure, such as alpha-pyrrolidinovalerophenone (α-PVP) or methylenedioxypyrovalerone (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants. Despite the known addictive potential of α-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine. Naphyrone increased time spent in the drug-paired compartment with 5 and 20 mg/kg s.c. being significant and 10 mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5 mg/kg s.c. The lowest dose, naphyrone 1 mg/kg s.c., had no effect on CPP. Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentanonas / Pirrolidinas / Comportamento Animal / Condicionamento Clássico / Transtornos Relacionados ao Uso de Substâncias / Estimulantes do Sistema Nervoso Central / Metanfetamina Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentanonas / Pirrolidinas / Comportamento Animal / Condicionamento Clássico / Transtornos Relacionados ao Uso de Substâncias / Estimulantes do Sistema Nervoso Central / Metanfetamina Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article