An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity.

Wei, Yanping; Tang, Xuewu; Ren, Yibin; Yang, Yun; Song, Fengliang; Fu, Jingbo; Liu, Shuowu; Yu, Miao; Chen, Jing; Wang, Suyang; Zhang, Kecheng; Tan, Yexiong; Han, Zhipeng; Wei, Lixin; Zhang, Baohua; Cheng, Zhangjun; Li, Liang; Wang, Hongyang

Wei, Yanping; Tang, Xuewu; Ren, Yibin; Yang, Yun; Song, Fengliang; Fu, Jingbo; Liu, Shuowu; Yu, Miao; Chen, Jing; Wang, Suyang; Zhang, Kecheng; Tan, Yexiong; Han, Zhipeng; Wei, Lixin; Zhang, Baohua; Cheng, Zhangjun; Li, Liang; Wang, Hongyang.

Afiliação

Wei Y; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Tang X; National Center for Liver Cancer, Shanghai, China.
Ren Y; National Center for Liver Cancer, Shanghai, China.
Yang Y; Hepato-Pancreato-biliary center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Song F; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Fu J; National Center for Liver Cancer, Shanghai, China.
Liu S; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Yu M; National Center for Liver Cancer, Shanghai, China.
Chen J; School of Medicine, Nantong University, Nantong, Jiangsu Province, China.
Wang S; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Zhang K; National Center for Liver Cancer, Shanghai, China.
Tan Y; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Han Z; National Center for Liver Cancer, Shanghai, China.
Wei L; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Zhang B; National Center for Liver Cancer, Shanghai, China.
Cheng Z; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.
Li L; National Center for Liver Cancer, Shanghai, China.
Wang H; International Co-operation Laboratory on Signal Transduction, Eastern Hepato-Biliary Surgery Institute, Second Military Medical University, Shanghai, China.

Signal Transduct Target Ther ; 6(1): 421, 2021 12 17.

Article em En | MEDLINE | ID: mdl-34916485

Assuntos

Antígeno B7-H1/metabolismo; Carcinogênese/metabolismo; Carcinoma Hepatocelular/metabolismo; Glutamina/metabolismo; Proteína HMGB1/metabolismo; Neoplasias Hepáticas Experimentais/metabolismo; Proteínas de Neoplasias/metabolismo; RNA Neoplásico/metabolismo; Proteína Companheira de mTOR Insensível à Rapamicina/metabolismo; Animais; Antígeno B7-H1/genética; Carcinogênese/genética; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/terapia; Linhagem Celular Tumoral; Glutamina/genética; Proteína HMGB1/genética; Imunoterapia; Neoplasias Hepáticas Experimentais/genética; Neoplasias Hepáticas Experimentais/terapia; Camundongos; Camundongos Nus; Proteínas de Neoplasias/genética; RNA Neoplásico/genética; Proteína Companheira de mTOR Insensível à Rapamicina/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Neoplásico / Carcinoma Hepatocelular / Proteína HMGB1 / Antígeno B7-H1 / Carcinogênese / Proteína Companheira de mTOR Insensível à Rapamicina / Glutamina / Neoplasias Hepáticas Experimentais / Proteínas de Neoplasias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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