Seasonal variation in serum metabolites of northern European dogs.
J Vet Intern Med
; 36(1): 190-195, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34921444
ABSTRACT
BACKGROUND:
Metabolic profiling identifies seasonal variance of serum metabolites in humans. Despite the presence of seasonal disease patterns, no studies have assessed whether serum metabolites vary seasonally in dogs.HYPOTHESIS:
There is seasonal variation in the serum metabolite profiles of healthy dogs. ANIMALS Eighteen healthy, client-owned dogs.METHODS:
A prospective cohort study. Serum metabolomic profiles were assessed monthly in 18 healthy dogs over a 12-month period. Metabolic profiling was conducted using a canine-specific proton nuclear magnetic resonance spectroscopy platform, and the effects of seasonality were studied for 98 metabolites using a cosinor model. Seasonal component was calculated, which describes the seasonal variation of each metabolite.RESULTS:
We found no evidence of seasonal variation in 93 of 98 metabolites. Six metabolites had statistically significant seasonal variance, including cholesterol (mean 249 mg/dL [6.47 mmol/L] with a seasonal component amplitude of 9 mg/dL [0.23 mmol/L]; 95% confidence interval [CI] 6-13 mg/dL [0.14-0.33 mmol/L], P < .008), with a peak concentration of 264 mg/dL (6.83 mmol/L) in June and trough concentration of 236 mg/dL (6.12 mmol/L) in December. In contrast, there was a significantly lower concentration of lactate (mean 20 mg/dL [2.27 mmol/L] with a seasonal component amplitude of 4 mg/dL [0.42 mmol/L]; 95% CI 2-6 mg/dL [0.22-0.62 mmol/L], P < .001) during the summer months compared to the winter months, with a peak concentration of 26 mg/dL (2.9 mmol/L) in February and trough concentration of 14 mg/dL (1.57 mmol/L) in July. CONCLUSIONS AND CLINICAL IMPORTANCE We found no clear evidence that seasonal reference ranges need to be established for serum metabolites of dogs.Palavras-chave
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colesterol
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article