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Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
Hindy, George; Dornbos, Peter; Chaffin, Mark D; Liu, Dajiang J; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C; Bielak, Lawrence F; Bis, Joshua C; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L; Bottinger, Erwin; Bowden, Donald W; Bown, Matthew J; Brody, Jennifer A; Broome, Jai G; Burtt, Noël P; Cade, Brian E; Centeno-Cruz, Federico; Chan, Edmund; Chang, Yi-Cheng; Chen, Yii-Der I; Cheng, Ching-Yu; Choi, Won Jung; Chowdhury, Rajiv; Contreras-Cubas, Cecilia; Córdova, Emilio J; Correa, Adolfo; Cupples, L Adrienne; Curran, Joanne E; Danesh, John; de Vries, Paul S; DeFronzo, Ralph A; Doddapaneni, Harsha; Duggirala, Ravindranath; Dutcher, Susan K; Ellinor, Patrick T; Emery, Leslie S.
Afiliação
  • Hindy G; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar.
  • Dornbos P; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
  • Chaffin MD; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Liu DJ; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.
  • Wang M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA 0
  • Selvaraj MS; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Zhang D; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Park J; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Aguilar-Salinas CA; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.
  • Antonacci-Fulton L; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Ardissino D; ASTC: Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy; Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; Universitˆ, degli Studi di Parma, Parma, Italy.
  • Arnett DK; Dean's Office, College of Public Health, University of Kentucky, Lexington, KY 40536, USA.
  • Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
  • Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; University of Haifa, Faculty of Natural Science, Haifa, Israel.
  • Ballantyne CM; Houston Methodist Debakey Heart and Vascular Center, Houston, TX 77030, USA; Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA.
  • Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
  • Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 49109, USA.
  • Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  • Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
  • Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Bottinger E; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany.
  • Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Bown MJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  • Broome JG; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Burtt NP; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
  • Cade BE; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
  • Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
  • Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taiwan.
  • Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Cheng CY; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore; Singapore Eye Research Institute, Singapore Natio
  • Choi WJ; Psomagen, Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850, USA.
  • Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Centre for Non-Communicable Disease Research, Bangladesh.
  • Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
  • Córdova EJ; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
  • Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; NHLBI Framingham Heart Study, Framingham, MA 01702, USA.
  • Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
  • Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.
  • de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
  • Dutcher SK; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Emery LS; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Am J Hum Genet ; 109(1): 81-96, 2022 01 06.
Article em En | MEDLINE | ID: mdl-34932938
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Fases de Leitura Aberta / Estudo de Associação Genômica Ampla / Exoma / Lipídeos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Fases de Leitura Aberta / Estudo de Associação Genômica Ampla / Exoma / Lipídeos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article