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Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors.
Bouquet, J; Auberger, N; Ashmus, R; King, D; Bordes, A; Fontelle, N; Nakagawa, S; Madden, Z; Proceviat, C; Kato, A; Désiré, J; Vocadlo, D J; Blériot, Y.
Afiliação
  • Bouquet J; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
  • Auberger N; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
  • Ashmus R; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5S 1P6, Canada. dvocadlo@sfu.ca.
  • King D; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5S 1P6, Canada. dvocadlo@sfu.ca.
  • Bordes A; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
  • Fontelle N; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
  • Nakagawa S; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. kato@med.u-toyama.ac.jp.
  • Madden Z; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5S 1P6, Canada. dvocadlo@sfu.ca.
  • Proceviat C; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5S 1P6, Canada. dvocadlo@sfu.ca.
  • Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. kato@med.u-toyama.ac.jp.
  • Désiré J; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
  • Vocadlo DJ; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5S 1P6, Canada. dvocadlo@sfu.ca.
  • Blériot Y; Université de Poitiers, IC2MP, UMR CNRS 7285, OrgaSynth Team, Glyco group, 4 rue Michel Brunet, 86073 Poitiers cedex 09, France. yves.bleriot@univ-poitiers.fr.
Org Biomol Chem ; 20(3): 619-629, 2022 01 19.
Article em En | MEDLINE | ID: mdl-34940771
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilglucosaminidase / Beta-N-Acetil-Hexosaminidases / Inibidores Enzimáticos / Imino Açúcares Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilglucosaminidase / Beta-N-Acetil-Hexosaminidases / Inibidores Enzimáticos / Imino Açúcares Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article