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Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.
Whiteway, Clémence; Valcek, Adam; Philippe, Chantal; Strazisar, Mojca; De Pooter, Tim; Mateus, Ivan; Breine, Anke; Van der Henst, Charles.
Afiliação
  • Whiteway C; Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, Brussels, Belgium.
  • Valcek A; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Philippe C; Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, Brussels, Belgium.
  • Strazisar M; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • De Pooter T; Research Unit in the Biology of Microorganisms (URBM), NARILIS, University of Namur (UNamur), Namur, Belgium.
  • Mateus I; Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
  • Breine A; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Van der Henst C; Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
ISME J ; 16(5): 1473-1477, 2022 05.
Article em En | MEDLINE | ID: mdl-34949784
ABSTRACT
We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article