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Sesquiterpenoids from Ixeris sonchifolia and their neuroprotective activities.
Yuan, Yan; Hu, Zhuo-Fan; Wang, Feng-Li; Wan, Luo-Sheng; Gong, Ying; Chen, Jia-Chun.
Afiliação
  • Yuan Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Hu ZF; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang FL; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
  • Wan LS; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Gong Y; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
  • Chen JC; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
J Asian Nat Prod Res ; 24(11): 1071-1077, 2022 Nov.
Article em En | MEDLINE | ID: mdl-34951327
The phytochemical investigation of the methanol extract of Ixeris sonchifolia led to the isolation and identification of nine analogs, including one new guaiane-type sesquiterpenoid, named ixerinoid A (1). The structure of 1 was determined by extensive analysis of the 1 D and 2 D nuclear magnetic resonance spectroscopic data, as well as quantum chemical calculations. Additionally, all the isolates were tested for their neuroprotective activity using the oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cell injury model. Compounds 3, 5, 6, 8, and 9 displayed remarkable protective effects at concentrations of 1, 5, and 10 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Traumatismo por Reperfusão / Fármacos Neuroprotetores / Asteraceae / Neuroblastoma Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Traumatismo por Reperfusão / Fármacos Neuroprotetores / Asteraceae / Neuroblastoma Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article