Nickel-Catalyzed Allylic Defluorinative Cross-Electrophile Coupling with Cycloalkyl Silyl Peroxides as the Alkyl Source.
J Org Chem
; 87(1): 892-903, 2022 01 07.
Article
em En
| MEDLINE
| ID: mdl-34958214
ABSTRACT
Herein we demonstrate the first successful application of cycloalkyl silyl peroxides (CSP) as an electrophilic coupling partner in the cross-electrophile coupling reaction. Diverse CSP are efficiently cross-coupled with an array of α-trifluoromethyl alkenes under the catalysis of nickel with the assistance of zinc as the reducing agent. This method allows the use of unstrained CSP as the carbonyl-containing alkyl source in the allylic defluorinative reaction, to access a variety of gem-difluoroalkenes bearing a pendent ketone moiety with high functionality tolerance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peróxidos
/
Níquel
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article