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Oral Cholera Vaccine Efficacy and Effectiveness.
Song, Katerina Rok; Lim, Jacqueline Kyungah; Park, Se Eun; Saluja, Tarun; Cho, Sung-Il; Wartel, Tram Anh; Lynch, Julia.
Afiliação
  • Song KR; International Vaccine Institute, Seoul 08826, Korea.
  • Lim JK; Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
  • Park SE; International Vaccine Institute, Seoul 08826, Korea.
  • Saluja T; International Vaccine Institute, Seoul 08826, Korea.
  • Cho SI; Graduate School of Public Health, Yonsei University, Seoul 03722, Korea.
  • Wartel TA; International Vaccine Institute, Seoul 08826, Korea.
  • Lynch J; Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
Vaccines (Basel) ; 9(12)2021 Dec 15.
Article em En | MEDLINE | ID: mdl-34960228
Although measuring vaccine efficacy through the conventional phase III study design, randomized, double-blinded controlled trial serves as the "gold standard", effectiveness studies, conducted in the context of a public health program, seek to broaden the understanding of the impact of a vaccine in a real world setting including both individual and population level impacts. Cholera is an acute diarrheal infection caused by the ingestion of food or water contaminated with the bacterium Vibrio cholerae. Since the 1980s, either killed or live oral cholera vaccines (OCVs) have been developed and efficacy and effectiveness studies have been conducted on OCV. Although the results of OCV effectiveness studies sometimes showed outliers, the tendency seen is for effectiveness of the vaccine used in public health settings to be somewhat higher than estimated in randomized controlled trials due to the influence of indirect herd protection. Efficacy and Effectiveness studies both generate important information about the vaccine performance characteristics and its impact when used in real world populations at risk for the disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2021 Tipo de documento: Article