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Novel strain of Pseudoruminococcus massiliensis possesses traits important in gut adaptation and host-microbe interactions.
Hiippala, Kaisa; Khan, Imran; Ronkainen, Aki; Boulund, Fredrik; Vähä-Mäkilä, Helena; Suutarinen, Maiju; Seifert, Maike; Engstrand, Lars; Satokari, Reetta.
Afiliação
  • Hiippala K; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Khan I; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Ronkainen A; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Boulund F; Centre for Translational Microbiome Research, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Vähä-Mäkilä H; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Suutarinen M; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Seifert M; Centre for Translational Microbiome Research, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Engstrand L; Centre for Translational Microbiome Research, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Satokari R; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Gut Microbes ; 14(1): 2013761, 2022.
Article em En | MEDLINE | ID: mdl-34965174
Fecal microbiota transplantation (FMT) is an efficient treatment for recurrent Clostridioides difficile infection and currently investigated as a treatment for other intestinal and systemic diseases. Better understanding of the species potentially transferred in FMT is needed. We isolated from a healthy fecal donor a novel strain E10-96H of Pseudoruminococcus massiliensis, a recently described strictly anaerobic species currently represented only by the type strain. The whole genome sequence of E10-96H had over 98% similarity with the type strain. E10-96H carries 20 glycoside hydrolase encoding genes, degrades starch in vitro and thus may contribute to fiber degradation, cross-feeding of other species and butyrate production in the intestinal ecosystem. The strain carries pilus-like structures, harbors pilin genes in its genome and adheres to enterocytes in vitro but does not provoke a proinflammatory response. P. massiliensis seems to have commensal behavior with the host epithelium, and its role in intestinal ecology should be studied further.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Firmicutes / Intestinos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Firmicutes / Intestinos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article